CTPS2

Across TCGA patient cohorts, CTPS2 mutation is significantly associated with the RNA expression of many other genes, with 2,136 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTPS2-associated genes across cancer lineages are NDUFAF5, PPP3CC, and RNF113A. Each is linked with CTPS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTPS2-to-partner and partner-to-CTPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFAF5 grouped by CTPS2-low versus CTPS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTPS2→partner) and Y-score (partner→CTPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFAF5 →	+0.392	+2.338	<.001	<.001	3	2
UCEC	PPP3CC →	+0.587	+2.284	<.001	<.001	3	2
UCEC	RNF113A →	+0.291	+2.255	.001	.001	3	2
UCEC	AOC2 →	+0.882	+2.284	<.001	<.001	3	2
COAD	RNU6-1241P →	+0.386	+7.741	<.001	.009	3	2
UCEC	EIF1 →	+0.344	+2.744	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,136 associations by consensus.

NDUFAF5 by CTPS2 expression — UCEC

Explore this box plot interactively →