CTPS2

Across TCGA patient cohorts, CTPS2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTPS2-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and JNK2. Each is linked with CTPS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTPS2-to-partner and partner-to-CTPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CTPS2-low versus CTPS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTPS2→partner) and Y-score (partner→CTPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.263	-2.321	.003	.001	3	1
UCEC	JNK_pT183_Y185 →	-0.143	-1.571	.018	.019	3	1
UCEC	JNK2 →	+0.241	+1.817	<.001	.015	3	1
UCEC	Ku80 →	+0.266	+2.820	.001	<.001	3	1
UCEC	MEK1 →	+0.335	+2.222	.010	.010	3	1
UCEC	Notch1 →	+0.138	+2.009	.006	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

EGFR_pY1068 by CTPS2 expression — UCEC

Explore this box plot interactively →