CTPS2

Across TCGA cell cohorts, CTPS2 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. CNS shows the largest number of these associations.

The most reproducible CTPS2-associated genes across cancer lineages are DPRX, PIWIL3, and KRTAP10-2. Each is linked with CTPS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTPS2-to-partner and partner-to-CTPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPRX grouped by CTPS2-low versus CTPS2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTPS2→partner) and Y-score (partner→CTPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DPRX →	+0.109	+5.060	<.001	.001	3	2
PANCREAS	PIWIL3 →	+0.011	+4.011	<.001	.009	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.041	+3.257	.002	.001	3	1
CNS	CFC1B →	+0.006	+4.357	<.001	.004	3	1
CNS	VPREB1 →	+0.338	+3.881	<.001	.003	3	1
CNS	ZNF729 →	+0.448	+3.643	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

DPRX by CTPS2 expression — BLOOD_Leukemia

Explore this box plot interactively →