CTPS1

Across TCGA pan-cancer cohorts, CTPS1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CTPS1 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CTPS1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CTPS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where CTPS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.784	0.478	<.001	45	view →
PDAC	DFS	Quartile	III,IV	0.708	0.166	.026	11	view →
LUAD	OS	Tertile	II,III,IV	0.493	0.813	.018	10	view →
CCRCC	OS	Tertile	All	0.711	1.000	.029	9	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CTPS1–HNSC (DFS)

Open the HNSC breakdown →