CTPS1

Across TCGA patient cohorts, CTPS1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTPS1-associated genes across cancer lineages are ERK2, MEK1, and PCNA. Each is linked with CTPS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTPS1-to-partner and partner-to-CTPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CTPS1-low versus CTPS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTPS1→partner) and Y-score (partner→CTPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.237	+2.459	<.001	<.001	3	2
UCEC	MEK1 →	+0.502	+2.938	<.001	<.001	3	2
UCEC	PCNA →	+0.232	+2.070	.001	.001	3	2
UCEC	Shc_pY317 →	-0.151	-2.222	.004	.010	3	2
UCEC	TFRC →	+0.422	+1.440	.022	.024	3	2
UCEC	TSC1 →	-0.142	-1.584	.016	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ERK2 by CTPS1 expression — UCEC

Explore this box plot interactively →