CTPS1

Across TCGA cell cohorts, CTPS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,945 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CTPS1-associated GO terms across cancer lineages are DNA strand elongation, Double-strand break repair via break-induced replication, and Positive regulation of cell cycle process. Each is linked with CTPS1 in more than 18 cancer types. Because this analysis shows association rather than direction, both CTPS1-to-partner and partner-to-CTPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA strand elongation grouped by CTPS1-low versus CTPS1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CTPS1→partner) and Y-score (partner→CTPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation →	+0.200	+1.505	<.001	<.001	3	19
BONE	Double-strand break repair via break-induced replication →	+0.263	+1.119	<.001	<.001	3	18
OESOPHAGUS	Positive regulation of cell cycle process →	+0.115	+0.992	.001	.006	3	18
UPPER_AERODIGESTIVE_TRACT	Regulation of cell cycle checkpoint →	+0.120	+1.227	<.001	<.001	3	18
BONE	DNA replication →	+0.125	+1.000	<.001	.001	3	18
BONE	DNA-templated DNA replication →	+0.167	+1.118	.001	.004	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,945 associations by consensus.

DNA strand elongation by CTPS1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →