CTNS

Across TCGA pan-cancer cohorts, CTNS mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CTNS data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CTNS mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CTNS expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where CTNS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.600	0.870	.011	3	view →
LUAD	OS	Median	All	0.841	0.616	.040	2	view →
HNSC	OS	Quartile	All	0.827	0.670	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CTNS–LSCC (OS)

Open the LSCC breakdown →