CTNS

Across TCGA patient cohorts, CTNS RNA expression is significantly associated with the mutation status of many other genes, with 9,083 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTNS-associated genes across cancer lineages are DOCK2, LAMA1, and IGSF10. Each is linked with CTNS in more than 3 cancer types. Because this analysis shows association rather than direction, both CTNS-to-partner and partner-to-CTNS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DOCK2 grouped by CTNS-low versus CTNS-high in SKCM.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNS→partner) and Y-score (partner→CTNS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DOCK2 →	+2.112	+0.290	.002	.005	3	4
COAD	LAMA1 →	+1.598	+0.230	<.001	.003	3	4
UCEC	IGSF10 →	+1.445	+0.238	<.001	.003	3	4
UCEC	DNAH2 →	+1.021	+0.232	<.001	.001	3	4
UCEC	KPRP →	+1.653	+0.352	<.001	<.001	3	4
PAAD	KRAS →	-1.178	-0.227	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,083 associations by consensus.

DOCK2 by CTNS expression — SKCM

Explore this box plot interactively →