CTNS

Across TCGA patient cohorts, CTNS mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTNS-associated genes across cancer lineages are Bax, 14-3-3_beta, and eEF2. Each is linked with CTNS in more than 1 cancer types. Because this analysis shows association rather than direction, both CTNS-to-partner and partner-to-CTNS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bax grouped by CTNS-low versus CTNS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNS→partner) and Y-score (partner→CTNS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bax →	+0.231	+2.817	.007	.001	3	2
UCEC	14-3-3_beta →	-0.109	-3.673	.002	.001	3	1
UCEC	eEF2 →	+0.393	+2.700	.002	.005	3	1
UCEC	EGFR_pY1068 →	-0.291	-2.321	.001	.001	3	1
UCEC	eIF4E →	+0.226	+2.807	.002	<.001	3	1
UCEC	A-Raf_pS299 →	-0.149	-2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Bax by CTNS expression — UCEC

Explore this box plot interactively →