CTNNBIP1

Across TCGA pan-cancer cohorts, CTNNBIP1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CTNNBIP1 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CTNNBIP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CTNNBIP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

PDAC, LUAD, and UCEC are the cancer types where CTNNBIP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	IV	0.250	0.934	.024	15	view →
LUAD	DFS	Tertile	II,III,IV	0.678	0.993	.016	10	view →
UCEC	OS	Quartile	All	1.000	0.835	.014	6	view →
LSCC	OS	Median	All	0.840	0.923	.018	6	view →
GBM	OS	Tertile	All	0.373	0.662	.024	5	view →
CCRCC	DFS	Tertile	All	0.947	0.589	.011	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CTNNBIP1–PDAC (DFS)

Open the PDAC breakdown →