CTNNBIP1

Across TCGA patient cohorts, CTNNBIP1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTNNBIP1-associated genes across cancer lineages are EGFR_pY1173, c-Met_pY1235, and HER3_pY1289. Each is linked with CTNNBIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTNNBIP1-to-partner and partner-to-CTNNBIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by CTNNBIP1-low versus CTNNBIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNNBIP1→partner) and Y-score (partner→CTNNBIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.104	+2.196	.012	.034	3	2
UCEC	c-Met_pY1235 →	+0.093	+2.817	.016	.036	3	2
UCEC	HER3_pY1289 →	+0.135	+3.348	.002	.005	3	1
UCEC	Ku80 →	+0.380	+2.183	.002	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.800	-3.308	<.001	.010	3	1
UCEC	p62 Lck ligand →	+0.629	+3.009	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

EGFR_pY1173 by CTNNBIP1 expression — UCEC

Explore this box plot interactively →