CTNNB1

Across TCGA patient cohorts, CTNNB1 protein abundance is significantly associated with the protein abundance of many other proteins, with 19,598 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CTNNB1-associated proteins across cancer lineages are ARHGEF6_S225, CTNNA1, and ANKRD44. Each is linked with CTNNB1 in more than 8 cancer types. Because this analysis shows association rather than direction, both CTNNB1-to-partner and partner-to-CTNNB1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CTNNB1 versus ARHGEF6_S225 in OV, with a Pearson correlation of -0.40.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNNB1→partner) and Y-score (partner→CTNNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ARHGEF6_S225 →	-0.784	-0.414	<.001	.004	3	9
COAD	CTNNA1 →	+0.444	+0.516	<.001	<.001	3	9
UCEC	ANKRD44 →	-0.393	-0.428	<.001	<.001	3	8
OV	ARHGAP30 →	-0.758	-0.442	<.001	.001	3	8
OV	BTK →	-0.758	-0.423	<.001	.003	3	8
BRCA	CDH1 →	+0.641	+0.393	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,598 associations by consensus.

CTNNB1 vs ARHGEF6_S225 — OV

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