CTNNB1

Across TCGA patient cohorts, CTNNB1 mutation is significantly associated with the total protein of many other genes, with 131 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible CTNNB1-associated genes across cancer lineages are CD49b, Bak, and cIAP. Each is linked with CTNNB1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CTNNB1-to-partner and partner-to-CTNNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD49b grouped by CTNNB1-low versus CTNNB1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNNB1→partner) and Y-score (partner→CTNNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	CD49b →	+0.414	+3.169	.001	.018	3	4
UCEC	Bak →	+0.137	+0.963	.003	.005	3	4
UCEC	cIAP →	+0.078	+0.948	.002	.002	3	4
STAD	eEF2 →	+0.304	+2.584	.016	.010	3	3
COAD	FASN →	+0.521	+3.095	<.001	<.001	3	3
COAD	NF-kB-p65_pS536 →	-0.698	-2.794	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 131 associations by consensus.

CD49b by CTNNB1 expression — STAD

Explore this box plot interactively →