CTNNB1

Across TCGA cell cohorts, CTNNB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,393 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CTNNB1-associated GO terms across cancer lineages are Negative regulation of chromosome condensation, Positive regulation of mRNA catabolic process, and Positive regulation of telomere maintenance via telomere lengthening. Each is linked with CTNNB1 in more than 13 cancer types. Because this analysis shows association rather than direction, both CTNNB1-to-partner and partner-to-CTNNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome condensation grouped by CTNNB1-low versus CTNNB1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNNB1→partner) and Y-score (partner→CTNNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of chromosome condensation →	+0.209	+0.895	<.001	<.001	3	14
SOFT_TISSUE	Positive regulation of mRNA catabolic process →	+0.079	+1.099	<.001	<.001	3	13
BREAST	Positive regulation of telomere maintenance via telomere lengthening →	+0.096	+1.262	<.001	.001	3	13
BREAST	Positive regulation of telomere maintenance via telomerase →	+0.103	+1.322	<.001	<.001	3	13
BREAST	Positive regulation of spindle checkpoint →	+0.168	+1.426	<.001	<.001	3	13
BREAST	Positive regulation of mitotic cell cycle spindle assembly checkpoint →	+0.168	+1.426	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,393 associations by consensus.

Negative regulation of chromosome condensation by CTNNB1 expression — SOFT_TISSUE

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