CTNNB1

Across TCGA cell cohorts, CTNNB1 mutation is significantly associated with the RNA expression of many other genes, with 708 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CTNNB1-associated genes across cancer lineages are FAM236A, GSG1L, and OR2B3. Each is linked with CTNNB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTNNB1-to-partner and partner-to-CTNNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM236A grouped by CTNNB1-low versus CTNNB1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNNB1→partner) and Y-score (partner→CTNNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	FAM236A →	+0.120	+5.357	<.001	.003	3	2
LUNG_NSCLC_LUAD	GSG1L →	+0.151	+3.994	.006	.002	3	2
BLOOD_Leukemia	OR2B3 →	+0.020	+3.551	.002	.009	3	2
LUNG_NSCLC_LUAD	TTC29 →	+1.126	+3.852	<.001	.003	3	1
LUNG_NSCLC_LUAD	PRR23D1 →	+0.011	+3.518	.006	.008	3	1
LUNG_NSCLC_LUAD	PRR23D2 →	+0.011	+3.518	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 708 associations by consensus.

FAM236A by CTNNB1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →