CTNNA2

Across TCGA patient cohorts, CTNNA2 mutation is significantly associated with the RNA expression of many other genes, with 7,011 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTNNA2-associated genes across cancer lineages are SPATA5L1, L2HGDH, and PSMB6. Each is linked with CTNNA2 in more than 5 cancer types. Because this analysis shows association rather than direction, both CTNNA2-to-partner and partner-to-CTNNA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA5L1 grouped by CTNNA2-low versus CTNNA2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNNA2→partner) and Y-score (partner→CTNNA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	SPATA5L1 →	+0.397	+3.609	.005	.001	3	6
STAD	L2HGDH →	+0.380	+2.725	.004	.002	3	5
UCEC	PSMB6 →	+0.368	+2.523	<.001	<.001	3	5
LUAD	BOLA3 →	+0.318	+1.540	.001	.001	3	5
LUAD	MTX1 →	+0.336	+1.686	<.001	.005	3	5
HNSC	PTCD2 →	+0.273	+2.637	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,011 associations by consensus.

SPATA5L1 by CTNNA2 expression — STAD

Explore this box plot interactively →