CTNNA2

Across TCGA patient cohorts, CTNNA2 mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTNNA2-associated genes across cancer lineages are Cyclin-B1, 4E-BP1_pS65, and Shc_pY317. Each is linked with CTNNA2 in more than 4 cancer types. Because this analysis shows association rather than direction, both CTNNA2-to-partner and partner-to-CTNNA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CTNNA2-low versus CTNNA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNNA2→partner) and Y-score (partner→CTNNA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.595	+1.378	<.001	.008	3	5
BLCA	4E-BP1_pS65 →	+0.150	+3.182	.031	.009	3	4
COAD	Shc_pY317 →	-0.151	-1.798	.003	.004	3	4
UCEC	C-Raf →	+0.112	+1.362	.008	.034	3	3
BRCA	P-Cadherin →	+0.287	+2.822	.015	.036	3	3
UCEC	JNK_pT183_Y185 →	-0.161	-1.807	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

Cyclin-B1 by CTNNA2 expression — UCEC

Explore this box plot interactively →