CTNNA2

Across TCGA cell cohorts, CTNNA2 mutation is significantly associated with the RNA expression of many other genes, with 174 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CTNNA2-associated genes across cancer lineages are SCGB2A1, MTRNR2L6, and EPRS1. Each is linked with CTNNA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CTNNA2-to-partner and partner-to-CTNNA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB2A1 grouped by CTNNA2-low versus CTNNA2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNNA2→partner) and Y-score (partner→CTNNA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SCGB2A1 →	+0.297	+2.517	.007	.006	2	3
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.130	+4.357	<.001	.006	3	2
LARGE_INTESTINE	EPRS1 →	+0.602	+3.321	<.001	.003	3	2
LARGE_INTESTINE	FMO2 →	+0.008	+1.747	.002	.004	3	2
PANCREAS	CPA3 →	+0.058	+3.700	<.001	.008	3	1
OESOPHAGUS	SCYGR2 →	+0.102	+3.857	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 174 associations by consensus.

SCGB2A1 by CTNNA2 expression — LARGE_INTESTINE

Explore this box plot interactively →