Across TCGA pan-cancer cohorts, CTNNA2-AS1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of CTNNA2-AS1’s most consistent transcriptional readouts.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where CTNNA2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types CTNNA2-AS1 is over-expressed in tumor, although a few such as UCEC show the opposite, repressed pattern.
UCEC and KICH are the cancer types where CTNNA2-AS1 tumor–normal differential expression is most reproducible.