CTNNA1

Across TCGA pan-cancer cohorts, CTNNA1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CTNNA1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CTNNA1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CTNNA1 is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

CCRCC, HNSC, and OV are the cancer types where CTNNA1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CTNNA1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	IV	−0.484	<.001	12	view →
HNSC	All	IV	−0.422	<.001	12	view →
OV	All	All	+0.406	.047	2	view →
PDAC	Female	All	−0.319	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

CTNNA1–CCRCC

Open the CCRCC breakdown →