CTNNA1

Across TCGA patient cohorts, CTNNA1 mutation is significantly associated with the RNA expression of many other genes, with 2,641 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTNNA1-associated genes across cancer lineages are RASSF1-AS1, CXXC1, and SKA1. Each is linked with CTNNA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CTNNA1-to-partner and partner-to-CTNNA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RASSF1-AS1 grouped by CTNNA1-low versus CTNNA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNNA1→partner) and Y-score (partner→CTNNA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RASSF1-AS1 →	+0.595	+2.706	<.001	<.001	3	3
COAD	CXXC1 →	+0.551	+3.820	<.001	<.001	3	3
COAD	SKA1 →	+0.805	+4.013	<.001	<.001	3	3
UCEC	SLC25A28 →	+0.266	+1.541	.001	.002	3	3
UCEC	PKN3 →	+0.632	+2.280	<.001	<.001	3	3
UCEC	CDC25A →	+0.496	+1.898	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,641 associations by consensus.

RASSF1-AS1 by CTNNA1 expression — UCEC

Explore this box plot interactively →