CTNNA1

Across TCGA patient cohorts, CTNNA1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTNNA1-associated genes across cancer lineages are 4E-BP1, beta-Catenin, and Caspase-7-cleavedD198. Each is linked with CTNNA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CTNNA1-to-partner and partner-to-CTNNA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CTNNA1-low versus CTNNA1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNNA1→partner) and Y-score (partner→CTNNA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.373	+3.000	.015	.036	3	3
UCEC	beta-Catenin →	+0.364	+2.115	.026	.016	3	3
COAD	Caspase-7-cleavedD198 →	+1.208	+3.016	<.001	.018	3	3
UCEC	Cyclin-B1 →	+0.540	+2.321	.002	.005	3	3
STAD	PTEN →	+0.516	+3.000	.017	.036	3	2
STAD	Src_pY527 →	-0.725	-3.000	.004	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

4E-BP1 by CTNNA1 expression — STAD

Explore this box plot interactively →