CTLA4

Across TCGA pan-cancer cohorts, CTLA4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CTLA4 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher CTLA4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CTLA4 expression acts as an unfavorable survival marker.

READ, LUAD, and LIHC are the cancer types where CTLA4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	All	0.198	0.829	.001	23	view →
LUAD	OS	Median	All	0.223	0.788	.002	21	view →
LIHC	DFS	Median	II,III,IV	0.102	0.429	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CTLA4–READ (OS)

Open the READ breakdown →