CTLA4

Across TCGA patient cohorts, CTLA4 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,521 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CTLA4-associated proteins across cancer lineages are CCDC88B_S597, CD2, and CORO1A. Each is linked with CTLA4 in more than 9 cancer types. Because this analysis shows association rather than direction, both CTLA4-to-partner and partner-to-CTLA4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CTLA4 versus CCDC88B_S597 in LSCC, with a Pearson correlation of 0.59.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CTLA4→partner) and Y-score (partner→CTLA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CCDC88B_S597 →	+0.818	+1.022	<.001	<.001	3	10
GBM	CD2 →	+1.237	+0.718	<.001	<.001	3	10
UCEC	CORO1A →	+0.859	+1.565	<.001	<.001	3	10
LSCC	COTL1 →	+0.585	+0.914	<.001	<.001	3	10
UCEC	DOCK10 →	+0.635	+1.255	<.001	.001	3	10
OV	DOCK2 →	+0.679	+1.224	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,521 associations by consensus.

CTLA4 vs CCDC88B_S597 — LSCC

Explore this scatter interactively →