CTLA4

Across TCGA cell cohorts, CTLA4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,799 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CTLA4-associated GO terms across cancer lineages are Nuclear DNA replication, Embryonic heart tube morphogenesis, and Protein deglycosylation involved in glycoprotein catabolic process. Each is linked with CTLA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both CTLA4-to-partner and partner-to-CTLA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear DNA replication grouped by CTLA4-low versus CTLA4-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CTLA4→partner) and Y-score (partner→CTLA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Nuclear DNA replication →	+0.087	+0.140	<.001	.003	3	4
SKIN	Embryonic heart tube morphogenesis →	+0.045	+0.910	.004	.004	3	3
SKIN	Protein deglycosylation involved in glycoprotein catabolic process →	+0.106	+0.895	<.001	.004	3	3
SKIN	Replacement ossification →	-0.125	-1.340	<.001	<.001	3	3
SKIN	Positive regulation of keratinocyte differentiation →	-0.100	-1.471	<.001	<.001	3	3
SKIN	Positive regulation of complement activation →	-1.400	-1.261	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,799 associations by consensus.

Nuclear DNA replication by CTLA4 expression — BLOOD_Leukemia

Explore this box plot interactively →