CTLA4

Across TCGA cell cohorts, CTLA4 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CTLA4-associated genes across cancer lineages are OR1L6, OR1L1, and GSG1L2. Each is linked with CTLA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTLA4-to-partner and partner-to-CTLA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L6 grouped by CTLA4-low versus CTLA4-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTLA4→partner) and Y-score (partner→CTLA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR1L6 →	+0.049	+5.029	<.001	.006	3	1
LUNG_SCLC	OR1L1 →	+0.052	+5.029	<.001	.006	3	1
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR1L6 by CTLA4 expression — LUNG_SCLC

Explore this box plot interactively →