CTIF

Across TCGA patient cohorts, CTIF mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTIF-associated genes across cancer lineages are A-Raf_pS299, 4E-BP1, and eIF4E. Each is linked with CTIF in more than 2 cancer types. Because this analysis shows association rather than direction, both CTIF-to-partner and partner-to-CTIF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by CTIF-low versus CTIF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTIF→partner) and Y-score (partner→CTIF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.094	-1.847	.014	.007	3	2
UCEC	4E-BP1 →	+0.291	+1.716	<.001	.003	2	3
UCEC	eIF4E →	+0.157	+1.906	.021	.015	2	2
UCEC	ERK2 →	+0.207	+2.999	<.001	<.001	3	1
UCEC	Heregulin →	-0.098	-1.986	.014	.029	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.490	+2.512	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

A-Raf_pS299 by CTIF expression — UCEC

Explore this box plot interactively →