CTIF

Across TCGA cell cohorts, CTIF mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CTIF-associated genes across cancer lineages are GFRA4, PPDPFL, and SCN11A. Each is linked with CTIF in more than 1 cancer types. Because this analysis shows association rather than direction, both CTIF-to-partner and partner-to-CTIF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by CTIF-low versus CTIF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTIF→partner) and Y-score (partner→CTIF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GFRA4 →	+0.019	+3.345	.001	.007	3	1
LARGE_INTESTINE	PPDPFL →	+0.040	+3.632	<.001	.003	3	1
LARGE_INTESTINE	SCN11A →	+0.124	+3.772	.002	.007	3	1
LARGE_INTESTINE	ARGFX →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	KRTAP10-6 →	+0.032	+3.347	.003	.005	3	1
LARGE_INTESTINE	ZNF679 →	+0.027	+3.347	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

GFRA4 by CTIF expression — LARGE_INTESTINE

Explore this box plot interactively →