CTHRC1

Across TCGA pan-cancer cohorts, CTHRC1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CTHRC1 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CTHRC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CTHRC1 expression acts as an unfavorable survival marker.

LSCC, CCRCC, and GBM are the cancer types where CTHRC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.509	0.862	.003	23	view →
CCRCC	DFS	Median	II,III,IV	0.235	0.887	.005	17	view →
GBM	OS	Quartile	All	0.276	0.514	.030	4	view →
PDAC	DFS	Tertile	IV	0.217	0.777	.024	3	view →
LUAD	DFS	Median	III,IV	0.595	0.885	.017	3	view →
HNSC	DFS	Quartile	IV	0.532	0.801	.034	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CTHRC1–LSCC (DFS)

Open the LSCC breakdown →