CTH

Across TCGA patient cohorts, CTH mutation is significantly associated with the RNA expression of many other genes, with 1,044 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTH-associated genes across cancer lineages are NTF6A, MIR4478, and MIR527. Each is linked with CTH in more than 1 cancer types. Because this analysis shows association rather than direction, both CTH-to-partner and partner-to-CTH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NTF6A grouped by CTH-low versus CTH-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTH→partner) and Y-score (partner→CTH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NTF6A →	+0.062	+5.912	<.001	.001	3	2
BRCA	MIR4478 →	+0.707	+5.259	<.001	.007	3	2
UCEC	MIR527 →	+0.216	+2.901	<.001	.009	3	2
UCEC	LINC00534 →	+0.144	+2.022	.001	.003	3	2
KIRP	CDY2A →	+0.025	+5.159	<.001	.007	3	2
LUAD	MTATP6P21 →	+0.160	+6.333	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,044 associations by consensus.

NTF6A by CTH expression — LUAD

Explore this box plot interactively →