CTH

Across TCGA patient cohorts, CTH mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTH-associated genes across cancer lineages are JNK2, MEK1, and p27. Each is linked with CTH in more than 1 cancer types. Because this analysis shows association rather than direction, both CTH-to-partner and partner-to-CTH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by CTH-low versus CTH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTH→partner) and Y-score (partner→CTH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.285	+3.584	.002	.002	3	1
UCEC	MEK1 →	+0.411	+3.169	.020	.019	3	1
UCEC	p27 →	-0.249	-2.999	.018	.035	3	1
UCEC	p62 Lck ligand →	+0.309	+3.009	.049	.019	3	1
UCEC	PCNA →	+0.236	+3.584	.024	.002	3	1
UCEC	PR →	-0.257	-3.169	.034	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

JNK2 by CTH expression — UCEC

Explore this box plot interactively →