CTDSPL2

Across TCGA pan-cancer cohorts, CTDSPL2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CTDSPL2 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CTDSPL2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CTDSPL2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, HNSC, and UCEC are the cancer types where CTDSPL2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	1.000	0.758	<.001	32	view →
HNSC	OS	Quartile	III,IV	0.791	0.968	.016	30	view →
UCEC	DFS	Median	All	0.852	0.957	.022	14	view →
PDAC	OS	Tertile	III,IV	0.411	0.938	.002	9	view →
CCRCC	OS	Median	III,IV	1.000	0.353	.022	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CTDSPL2–LSCC (OS)

Open the LSCC breakdown →