CTDSPL2

Across TCGA patient cohorts, CTDSPL2 mutation is significantly associated with the RNA expression of many other genes, with 2,812 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTDSPL2-associated genes across cancer lineages are PSAT1P4, UBL5P4, and NDUFB4P5. Each is linked with CTDSPL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CTDSPL2-to-partner and partner-to-CTDSPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSAT1P4 grouped by CTDSPL2-low versus CTDSPL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTDSPL2→partner) and Y-score (partner→CTDSPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSAT1P4 →	+0.110	+1.663	.003	.001	3	3
BLCA	UBL5P4 →	+0.175	+3.840	.004	.006	3	2
CESC	NDUFB4P5 →	+0.128	+5.969	<.001	.002	3	2
UCEC	RNA5SP412 →	+0.593	+2.041	<.001	<.001	3	2
SARC	LINC02503 →	+0.066	+5.954	<.001	.002	3	2
LUAD	DEFB122 →	+0.084	+4.554	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,812 associations by consensus.

PSAT1P4 by CTDSPL2 expression — UCEC

Explore this box plot interactively →