CTDSPL2

Across TCGA patient cohorts, CTDSPL2 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTDSPL2-associated genes across cancer lineages are CD49b, 14-3-3_beta, and EGFR_pY1068. Each is linked with CTDSPL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTDSPL2-to-partner and partner-to-CTDSPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD49b grouped by CTDSPL2-low versus CTDSPL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTDSPL2→partner) and Y-score (partner→CTDSPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD49b →	-0.350	-3.886	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.079	-2.558	.025	.010	3	1
UCEC	EGFR_pY1068 →	-0.251	-2.321	.004	.005	3	1
UCEC	eIF4E →	+0.201	+2.392	.007	<.001	3	1
UCEC	eIF4G →	+0.291	+3.459	.007	.005	3	1
UCEC	A-Raf_pS299 →	-0.120	-1.906	.004	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

CD49b by CTDSPL2 expression — UCEC

Explore this box plot interactively →