CTDSPL

Across TCGA patient cohorts, CTDSPL mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTDSPL-associated genes across cancer lineages are MSH2, PRDX1, and 4E-BP1. Each is linked with CTDSPL in more than 1 cancer types. Because this analysis shows association rather than direction, both CTDSPL-to-partner and partner-to-CTDSPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by CTDSPL-low versus CTDSPL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTDSPL→partner) and Y-score (partner→CTDSPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.358	-2.295	<.001	.033	3	2
UCEC	PRDX1 →	+0.206	+2.459	.009	.018	3	2
UCEC	4E-BP1 →	+0.318	+1.678	.002	.023	3	2
UCEC	EGFR_pY1068 →	-0.242	-1.678	.012	.023	3	1
UCEC	Fibronectin →	-0.258	-2.986	.041	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.114	-2.105	.017	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

MSH2 by CTDSPL expression — UCEC

Explore this box plot interactively →