CTDSPL

Across TCGA cell cohorts, CTDSPL mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CTDSPL-associated genes across cancer lineages are MSGN1, COX4I2, and CFC1. Each is linked with CTDSPL in more than 1 cancer types. Because this analysis shows association rather than direction, both CTDSPL-to-partner and partner-to-CTDSPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by CTDSPL-low versus CTDSPL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTDSPL→partner) and Y-score (partner→CTDSPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
BLOOD_Leukemia	COX4I2 →	+0.733	+4.276	<.001	.007	3	1
BLOOD_Leukemia	CFC1 →	+0.016	+4.539	<.001	.007	3	1
BLOOD_Leukemia	ASZ1 →	+0.114	+4.152	.002	.009	3	1
BLOOD_Leukemia	FAM236A →	+0.097	+5.269	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MSGN1 by CTDSPL expression — LARGE_INTESTINE

Explore this box plot interactively →