CTDNEP1

Across TCGA patient cohorts, CTDNEP1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTDNEP1-associated genes across cancer lineages are FoxM1, JNK2, and Paxillin. Each is linked with CTDNEP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTDNEP1-to-partner and partner-to-CTDNEP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by CTDNEP1-low versus CTDNEP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTDNEP1→partner) and Y-score (partner→CTDNEP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.446	+3.000	.002	.037	3	1
UCEC	JNK2 →	+0.293	+3.000	.010	.037	3	1
UCEC	Paxillin →	+0.371	+3.000	.013	.037	3	1
UCEC	PRAS40_pT246 →	+0.231	+3.013	.019	.019	3	1
UCEC	Rab25 →	-0.582	-3.000	.002	.037	3	1
UCEC	Shc_pY317 →	-0.326	-3.000	<.001	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

FoxM1 by CTDNEP1 expression — UCEC

Explore this box plot interactively →