CTCFL

Across TCGA cell cohorts, CTCFL mutation is significantly associated with the RNA expression of many other genes, with 163 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CTCFL-associated genes across cancer lineages are RD3L, OR5P2, and KRTAP6-1. Each is linked with CTCFL in more than 1 cancer types. Because this analysis shows association rather than direction, both CTCFL-to-partner and partner-to-CTCFL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RD3L grouped by CTCFL-low versus CTCFL-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTCFL→partner) and Y-score (partner→CTCFL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RD3L →	+0.032	+5.029	<.001	.006	3	1
SKIN	OR5P2 →	+0.030	+4.684	.004	.002	3	1
SKIN	KRTAP6-1 →	+0.075	+5.022	<.001	.002	3	1
SKIN	CLEC9A →	+0.019	+4.467	<.001	.004	3	1
SKIN	CT45A6 →	+0.090	+4.095	.002	.009	3	1
SKIN	NCR2 →	+0.015	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 163 associations by consensus.

RD3L by CTCFL expression — LUNG_SCLC

Explore this box plot interactively →