CTCF

Across TCGA pan-cancer cohorts, CTCF mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CTCF data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CTCF mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CTCF expression acts as an unfavorable survival marker, although some lineages such as COAD show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where CTCF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.887	.022	18	view →
CCRCC	OS	Tertile	All	0.881	1.000	.011	13	view →
PDAC	DFS	Tertile	II,III,IV	0.279	0.453	.011	5	view →
HNSC	DFS	Median	III,IV	0.712	0.858	.027	3	view →
LSCC	DFS	Median	All	0.905	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CTCF–COAD (DFS)

Open the COAD breakdown →