CTCF

Across TCGA patient cohorts, CTCF protein abundance is significantly associated with the RNA expression of many other genes, with 9,231 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CTCF-associated genes across cancer lineages are CXCL8, G0S2, and TREM1. Each is linked with CTCF in more than 5 cancer types. Because this analysis shows association rather than direction, both CTCF-to-partner and partner-to-CTCF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CTCF versus CXCL8 in GBM, with a Pearson correlation of -0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTCF→partner) and Y-score (partner→CTCF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CXCL8 →	-1.969	-0.601	<.001	<.001	3	6
BRCA	G0S2 →	-1.613	-0.271	<.001	<.001	3	5
GBM	TREM1 →	-1.469	-0.516	<.001	<.001	3	5
GBM	IL1RN →	-1.187	-0.467	<.001	<.001	3	5
COAD	FCGR3B →	-1.445	-0.246	<.001	<.001	3	5
GBM	SLC11A1 →	-1.347	-0.511	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,231 associations by consensus.

CTCF vs CXCL8 — GBM

Explore this scatter interactively →