CTCF

Across TCGA patient cohorts, CTCF mutation is significantly associated with the RNA expression of many other genes, with 3,363 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTCF-associated genes across cancer lineages are NUDT9, MINAR2, and MMAA. Each is linked with CTCF in more than 3 cancer types. Because this analysis shows association rather than direction, both CTCF-to-partner and partner-to-CTCF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUDT9 grouped by CTCF-low versus CTCF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTCF→partner) and Y-score (partner→CTCF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUDT9 →	+0.226	+1.398	.001	.003	3	4
READ	MINAR2 →	+0.083	+4.361	<.001	.006	3	3
BRCA	MMAA →	+0.414	+3.807	.001	<.001	3	3
BRCA	ACOT4 →	+0.755	+2.700	.009	.007	3	3
BRCA	FDXACB1 →	+0.812	+3.503	<.001	.002	3	3
UCEC	ZNF174 →	+0.194	+1.409	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,363 associations by consensus.

NUDT9 by CTCF expression — UCEC

Explore this box plot interactively →