CTCF

Across TCGA patient cohorts, CTCF mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTCF-associated genes across cancer lineages are p27_pT157, Chk2_pT68, and 14-3-3_beta. Each is linked with CTCF in more than 1 cancer types. Because this analysis shows association rather than direction, both CTCF-to-partner and partner-to-CTCF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT157 grouped by CTCF-low versus CTCF-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTCF→partner) and Y-score (partner→CTCF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	p27_pT157 →	-0.140	-2.308	.044	.037	3	2
BRCA	Chk2_pT68 →	-0.371	-2.321	.012	.037	3	2
UCEC	14-3-3_beta →	-0.078	-1.156	<.001	.001	3	2
UCEC	P-Cadherin →	-0.071	-1.392	.032	.015	3	2
UCEC	PI3K-p85 →	+0.102	+1.067	.034	.002	3	2
UCEC	PKC-delta_pS664 →	-0.070	-1.000	.011	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

p27_pT157 by CTCF expression — BRCA

Explore this box plot interactively →