CTCF

Across TCGA cell cohorts, CTCF mutation is significantly associated with the RNA expression of many other genes, with 2,219 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CTCF-associated genes across cancer lineages are PPP6R2, RHBDD3, and CBX7. Each is linked with CTCF in more than 1 cancer types. Because this analysis shows association rather than direction, both CTCF-to-partner and partner-to-CTCF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP6R2 grouped by CTCF-low versus CTCF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTCF→partner) and Y-score (partner→CTCF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP6R2 →	+0.691	+2.936	<.001	<.001	3	2
LARGE_INTESTINE	RHBDD3 →	+0.742	+2.850	.003	<.001	3	2
LARGE_INTESTINE	CBX7 →	+0.851	+2.409	<.001	.003	3	2
LARGE_INTESTINE	TNRC6B →	+0.936	+2.850	<.001	<.001	3	2
LARGE_INTESTINE	ST13 →	+0.540	+2.850	<.001	<.001	3	2
LARGE_INTESTINE	ZC3H14 →	+0.550	+2.850	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,219 associations by consensus.

PPP6R2 by CTCF expression — LARGE_INTESTINE

Explore this box plot interactively →