CTC1

Across TCGA patient cohorts, CTC1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTC1-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and ACC1. Each is linked with CTC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CTC1-to-partner and partner-to-CTC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CTC1-low versus CTC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTC1→partner) and Y-score (partner→CTC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.746	+1.637	<.001	.001	3	3
UCEC	eIF4E →	+0.133	+1.637	.032	.001	3	2
UCEC	ACC1 →	+0.226	+1.498	.035	.032	3	2
UCEC	PRDX1 →	+0.143	+1.662	.018	.010	3	2
UCEC	Src_pY527 →	-0.258	-1.668	.041	.021	3	2
UCEC	ASNS →	+0.423	+1.716	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Caspase-7-cleavedD198 by CTC1 expression — UCEC

Explore this box plot interactively →