CTC1

Across TCGA cell cohorts, CTC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,403 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CTC1-associated GO terms across cancer lineages are Negative regulation of telomere maintenance via telomerase, Late endosome to Golgi transport, and Negative regulation of telomere maintenance. Each is linked with CTC1 in more than 15 cancer types. Because this analysis shows association rather than direction, both CTC1-to-partner and partner-to-CTC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of telomere maintenance via telomerase grouped by CTC1-low versus CTC1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CTC1→partner) and Y-score (partner→CTC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of telomere maintenance via telomerase →	+0.098	+1.251	<.001	<.001	3	16
LIVER	Late endosome to Golgi transport →	+0.190	+0.989	<.001	.003	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of telomere maintenance →	+0.102	+1.244	<.001	<.001	3	15
BONE	Negative regulation of telomere maintenance via telomere lengthening →	+0.074	+0.918	.002	.007	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair →	+0.070	+0.898	.001	.001	3	14
BONE	Telomere organization →	+0.105	+1.193	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,403 associations by consensus.

Negative regulation of telomere maintenance via telomerase by CTC1 expression — URINARY_TRACT

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