CTC1

Across TCGA cell cohorts, CTC1 mutation is significantly associated with the RNA expression of many other genes, with 893 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CTC1-associated genes across cancer lineages are CBLIF, C1QC, and KSR2. Each is linked with CTC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTC1-to-partner and partner-to-CTC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBLIF grouped by CTC1-low versus CTC1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTC1→partner) and Y-score (partner→CTC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CBLIF →	+0.086	+4.635	<.001	.003	3	2
BLOOD_Myeloma	C1QC →	+0.246	+4.807	<.001	.006	3	2
LARGE_INTESTINE	KSR2 →	+0.415	+3.364	.005	.002	3	2
LARGE_INTESTINE	NUTM1 →	+0.047	+2.894	.002	.002	3	2
LARGE_INTESTINE	ADAM7 →	+0.003	+2.538	<.001	.005	3	2
LARGE_INTESTINE	F11 →	+0.028	+2.619	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 893 associations by consensus.

CBLIF by CTC1 expression — SOFT_TISSUE

Explore this box plot interactively →