CTBS

Across TCGA pan-cancer cohorts, CTBS mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CTBS data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CTBS mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CTBS expression acts as an unfavorable survival marker, although some lineages such as GBM and UCEC show a favorable association.

LUAD, GBM, and UCEC are the cancer types where CTBS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.877	1.000	.001	20	view →
GBM	OS	Quartile	All	0.671	0.252	.003	6	view →
UCEC	DFS	Tertile	II,III,IV	0.889	0.454	.023	4	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	3	view →
LSCC	OS	Quartile	All	0.780	0.949	.045	2	view →
CCRCC	DFS	Median	III,IV	0.439	0.699	.041	2	view →
HNSC	DFS	Median	III,IV	0.939	1.000	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CTBS–LUAD (OS)

Open the LUAD breakdown →