CTBS

Across TCGA patient cohorts, CTBS protein abundance is significantly associated with the RNA expression of many other genes, with 16,943 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CTBS-associated genes across cancer lineages are EXOSC2, CCDC170, and AIF1L. Each is linked with CTBS in more than 5 cancer types. Because this analysis shows association rather than direction, both CTBS-to-partner and partner-to-CTBS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CTBS versus EXOSC2 in LSCC, with a Pearson correlation of -0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTBS→partner) and Y-score (partner→CTBS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EXOSC2 →	-0.574	-0.338	<.001	<.001	3	6
BRCA	CCDC170 →	+1.850	+0.515	<.001	<.001	3	6
BRCA	AIF1L →	-1.167	-0.344	<.001	<.001	3	5
LSCC	SMC2 →	-0.847	-0.427	<.001	<.001	3	5
LSCC	HR →	-1.392	-0.311	<.001	<.001	3	5
LSCC	NELFB →	-0.477	-0.286	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,943 associations by consensus.

CTBS vs EXOSC2 — LSCC

Explore this scatter interactively →