CTBS

Across TCGA patient cohorts, CTBS mutation is significantly associated with the RNA expression of many other genes, with 3,271 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTBS-associated genes across cancer lineages are FXYD6P3, RNU6-939P, and IGHD3-22. Each is linked with CTBS in more than 1 cancer types. Because this analysis shows association rather than direction, both CTBS-to-partner and partner-to-CTBS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FXYD6P3 grouped by CTBS-low versus CTBS-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTBS→partner) and Y-score (partner→CTBS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	FXYD6P3 →	+0.195	+5.899	<.001	.002	3	2
PRAD	RNU6-939P →	+0.279	+7.939	<.001	.008	3	2
UCEC	IGHD3-22 →	+1.725	+2.006	<.001	<.001	3	2
SKCM	MIR588 →	+0.719	+6.328	<.001	.001	3	2
SKCM	MIR450B →	+0.388	+4.979	<.001	.009	3	2
COAD	MIR8052 →	+0.442	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,271 associations by consensus.

FXYD6P3 by CTBS expression — BLCA

Explore this box plot interactively →