CTBS

Across TCGA patient cohorts, CTBS mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTBS-associated genes across cancer lineages are S6_pS240_S244, 14-3-3_beta, and EGFR. Each is linked with CTBS in more than 1 cancer types. Because this analysis shows association rather than direction, both CTBS-to-partner and partner-to-CTBS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by CTBS-low versus CTBS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTBS→partner) and Y-score (partner→CTBS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.342	+2.321	.019	.034	3	2
UCEC	14-3-3_beta →	-0.083	-1.847	.022	.049	3	1
UCEC	EGFR →	-0.216	-2.558	<.001	.010	3	1
UCEC	eIF4E →	+0.216	+3.906	.004	<.001	3	1
UCEC	A-Raf_pS299 →	-0.109	-2.115	.011	.017	3	1
UCEC	FASN →	+0.382	+2.115	.007	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

S6_pS240_S244 by CTBS expression — UCEC

Explore this box plot interactively →